Endocrine Abstracts

Introduction: Osteoporosis is a silent disease and fractures pose enormous medical and financial burden on ageing individuals. Also subjects of younger age are at risk for subnormal bone mineral density when they have systemic disorders like rheumatoid arthritis or on long-term medications like corticosteroids. Preventive measures can be initiated if osteoporosis is diagnosed and treated before any fracture occurs. Even after the first fracture has occurred, there are effectiv...

Introduction: Glycaemic variability has been proposed as a contributing factor for development of diabetes related complications. This concept originated from Epidemiology of Diabetes Interventions and Complications (EDIC) study, in which, although the HbA1C was similar in conventional and intensively treated groups, the incidence of retinopathy was higher in the conventional group. This was attributed to glycaemic variability. Studying glycaemic variability in prediabetes wou...

Introduction: There are many reports describing the association of alternations of bone and mineral metabolism in patients with epilepsy receiving long term anticonvulsant therapy. However, there are only a few Indian studies which have looked at this aspect. Objective: This study was done to compare the prevalence of changes in bone mineral parameters and bone mineral density (BMD) in ambulant individuals on long term anticonvulsant therapy with age and BMI matched healthy co...

Objective: To assess the metabolic characteristics, body composition, Insulin resistance and energy expenditure in young South Indian males with low and normal birth weight.Methodology: A population based cohort of 43 low birth weight (<2.5 kg) and 41 normal birth weight (>2.5 kg) subjects born at term was taken from a rural part in the South Indian state of Tamilnadu. Young healthy males aged 18–22 years were recruited. Following informed c...

Background: Pituitary apoplexy is a neurological emergency, whose prevalence is generally underestimated. The overall prevalence ranges from 0.6 to 27.7% of all pituitary tumours.Methodology: Retrospective analysis of hospital medical records of 274 patients with pituitary adenoma who presented to us between 1996–2006 was done.Results: Of the 274 patients analysed, 84 had features of pituitary apoplexy (31%) Mean age was 44.7 ...

Background: Pheochromocytomas are tumors arising from chromaffin cells diagnosed in <1% of patient evaluated for hypertension.Methodology: A retrospective analysis of case records of those patients with histopathologically confirmed pheochromocytoma in our hospital from 1993–2006 (14 years) was conducted.Result: A total of 94 patients were diagnosed to have pheochromocytoma during this period. The median age at presentatio...

Aims: To calculate the sensitivity, specificity and positive predictive value of Parathyroid scintigraphy using Technetium-Sestamibi scan in the localization of parathyroid disease.Methods and material: This is a retrospective medical review of 161 patients who underwent the Parathyroid scintigraphy at our hospital in last six years. True positives were defined as patients with confirmed primary hyperparathyroidism (PHPT) on pathological examination. Tru...

Background: Insulinoma is an uncommon disease. The clinical profile of insulinomas among Indian patients is not well known.Aim of the study: To study the clinical characterstics, biochemical and radiological parameters,and treatment aspects of our adult patients with insulinomas.Methodology: We did a retrospective analysis of 18 patients with insulinoma treated from 1992 to 2004 in our institution. The data was analysed using a 11....

Aim: To analyse the clinical profile in patients with differentiated thyroid carcinoma.Materials & Methods: A retrospective analysis of case records of 232 patients who had under gone treatment for differentiated thyroid carcinoma from year 2000–2004 in Christian Medical College, Vellore was done and the intended data obtained using spss data.Results: A preoperative FNAC suggested thyroid neoplasm in 60%. Total thyroidecto...

Aims: To study changes in bone mineral density (BMD), bone mineral parameters, metabolic profile, body composition and quality of life at base line and 6 months following parathyroidectomy, in subjects with primary hyperparathyroidism (PHPT).Material and methods: This prospective study was conducted over 18 months with first 12 months of recruitment and next 6 months for follow-up. Sixty-eight patients with PHPT who underwent surgery were compared with 1...